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ENMD-1068 hydrochloride (Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride)

Katalog-Nr.GC60807

ENMD-1068-Hydrochlorid ist ein selektiver Protease-aktivierter Rezeptor 2 (PAR2)-Antagonist mit antiangiogener und entzÜndungshemmender Wirkung.

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ENMD-1068 hydrochloride Chemische Struktur

Cas No.: 789488-77-3

Größe Preis Lagerbestand Menge
10mM (in 1mL DMSO)
97,00 $
Auf Lager
5mg
88,00 $
Auf Lager
10mg
158,00 $
Auf Lager
25mg
324,00 $
Auf Lager
50mg
556,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist with antiangiogenic and anti-inflammatory activities. ENMD-1068 hydrochloride reduces epatic stellate cells (HSCs) activation and collagen expression through the inhibiton of TGF-β1/Smad signal transduction[1][2].

[1]. Yifeng Wang, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8. [2]. Quan Sun, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498.

Chemical Properties

Cas No. 789488-77-3 SDF
Überlieferungen 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
Canonical SMILES O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN.Cl
Formula C15H30ClN3O2 M.Wt 319.87
Löslichkeit Water: 25 mg/mL, clear Storage Desiccated at 2-8°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.1263 mL 15.6314 mL 31.2627 mL
5 mM 0.6253 mL 3.1263 mL 6.2525 mL
10 mM 0.3126 mL 1.5631 mL 3.1263 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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