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GA-017

Katalog-Nr.GC65116

GA-017 ist ein potenter und selektiver LATS1- und LATS2-Inhibitor (Large Tumor Suppressor Kinase 1/2) mit IC50-Werten von 4,10 bzw. 3,92 nM. GA-017 ist ein Aktivator der Zellproliferation. GA-017 fÖrdert die YAP/TAZ-Aktivierung und Kerntranslokation. GA-017 fÖrdert das Zellwachstum unter 3D-Kulturbedingungen. GA-017 verstÄrkt die Ex-vivo-Bildung von Maus-Darm-Organoiden.

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GA-017 Chemische Struktur

Cas No.: 2351906-74-4

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10mg
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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Background

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].

GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1].

[1]. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.

Chemical Properties

Cas No. 2351906-74-4 SDF Download SDF
Formula C18H21N3O4 M.Wt 343.38
Löslichkeit DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9122 mL 14.5611 mL 29.1223 mL
5 mM 0.5824 mL 2.9122 mL 5.8245 mL
10 mM 0.2912 mL 1.4561 mL 2.9122 mL
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