(R)-CE3F4 |
| Katalog-Nr.GC34988 |
(R)-CE3F4 ist ein potenter und selektiver Inhibitor des Austauschproteins, das direkt durch cAMP-Isoform 1 (Epac1) aktiviert wird, mit einem IC50 von 4,2 μM und einer 10-fachen SelektivitÄt fÜr Epac1 gegenÜber Epac2 (IC50, 44 μM).
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Cas No.: 1593478-56-8
Sample solution is provided at 25 µL, 10mM.
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(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1].
[1]. Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.
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