ACBI1 |
| Katalog-Nr.GC35227 |
ACBI1 ist ein potenter und kooperativer SMARCA2-, SMARCA4- und PBRM1-Abbaustoff mit DC50-Werten von 6, 11 bzw. 32 nM. ACBI1 ist ein PROTAC-Degrader. ACBI1 zeigt antiproliferative AktivitÄt. ACBI1 induziert Apoptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2375564-55-7
Sample solution is provided at 25 µL, 10mM.
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ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis[1]. DC50: 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)[1]
[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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