Bruceine D |
| Katalog-Nr.GC35559 |
Bruceine D ist ein Notch-Inhibitor mit Anti-Krebs-AktivitÄt und induziert Apoptose in mehreren menschlichen Krebszellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21499-66-1
Sample solution is provided at 25 µL, 10mM.
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Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Notch[1]
Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6?μM, respectively, at 48?h of treatment[1]. Bruceine D (0.125-1.0?μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].
[1]. Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. [2]. Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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