Fluorofenidone (Synonyms: AKF-PD) |
| Katalog-Nr.GC38114 |
Fluorofenidon (AKF-PD), ein Analogon von AMR69, zeigt eine gleichwertige antifibrotische AktivitÄt, eine geringere ToxizitÄt und eine lÄngere Halbwertszeit.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 848353-85-5
Sample solution is provided at 25 µL, 10mM.
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Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
[1]. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. [2]. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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