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(±)-Ketoprofen-d3 (Synonyms: (R,S)-Ketoprofen-d3, 2-(3-benzoylphenyl)Propionic Acid-d3)

Katalog-Nr.GC45278

 

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(±)-Ketoprofen-d3 Chemische Struktur

Cas No.: 159490-55-8

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-Ketoprofen-d3 is intended for use as an internal standard for the quantification of (±)-ketoprofen by GC- or LC-MS. (±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 μM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant.2 Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.

References
1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys. Acta. 1209(1), 130-139 (1994).
2. Zhang, J., Xu, X., Zhu, L., et al. Preparation and pre-clinical characterization of sustained release ketoprofen implants for the management of pain and inflammation in osteoarthritis. Trop. J. Pharm. Res. 17(4), 577-582 (2018).

Chemical Properties

Cas No. 159490-55-8 SDF
Überlieferungen (R,S)-Ketoprofen-d3, 2-(3-benzoylphenyl)Propionic Acid-d3
Canonical SMILES O=C(C1=CC=CC(C(C(O)=O)C([2H])([2H])[2H])=C1)C2=CC=CC=C2
Formula C16H11D3O3 M.Wt 257.3
Löslichkeit DMSO: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.8865 mL 19.4326 mL 38.8651 mL
5 mM 0.7773 mL 3.8865 mL 7.773 mL
10 mM 0.3887 mL 1.9433 mL 3.8865 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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