GPX4 Inhibitor 17 (Synonyms: Glutathione Peroxidase 4-IN-17; Glutathione Peroxidase 4 Inhibitor 17; GPX4-IN-17) |
| Katalog-Nr.GC92031 |
GPX4 Inhibitor 17 ist ein ferrocenhaltiger Inhibitor der Glutathionperoxidase 4 (GPX4) und ein Induktor der Ferroptose.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.1 It inhibits GPX4 activity by 49.16% when used at a concentration of 1 ?M. GPX4 inhibitor 17 (0.5 ?M) increases the production of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) in OS-RC-2 clear cell renal cell carcinoma cells. It induces ferroptosis in HT-1080 cells (IC50s = 0.007 and 1.486 ?M, in the absence and presence of ferrostatin-1, respectively). GPX4 inhibitor 17 (20 mg/kg) reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 mouse xenograft model.
References:
[1]. Li, W., Yu, J., Wang, J., et al.How does ferrocene correlate with ferroptosis Multiple approaches to explore ferrocene-appended GPX4 inhibitors as anticancer agentsChem. Sci.15(27)10477-10490(2024).
| Cas No. | SDF | ||
| Überlieferungen | Glutathione Peroxidase 4-IN-17; Glutathione Peroxidase 4 Inhibitor 17; GPX4-IN-17 | ||
| Canonical SMILES | [][Fe][].O=C(C#C)N(C1=CC=C(OC)C(Cl)=C1)C(c2cccc2)C(NCCC3=CC=CC=C3)=O.c4cccc4 | ||
| Formula | C30H27ClFeN2O3 | M.Wt | 554.9 |
| Löslichkeit | DMSO: Soluble: ≥10 mg/ml,Ethanol: Sparingly soluble: 1-10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8021 mL | 9.0106 mL | 18.0213 mL |
| 5 mM | 0.3604 mL | 1.8021 mL | 3.6043 mL |
| 10 mM | 0.1802 mL | 0.9011 mL | 1.8021 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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