Peptide YY (human) (trifluoroacetate salt) (Synonyms: Peptide Tyrosine Tyrosine) |
| Katalog-Nr.GC44598 |
Peptide YY (human) (trifluoroacetate salt) is a peptide hormone secreted by intestinal L cells.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Peptide YY (human) (trifluoroacetate salt) is a peptide hormone secreted by intestinal L cells [1]. Peptide YY binds to Y2 receptors on the hypothalamus and vagus nerve, inhibiting the release of neuropeptide Y, thereby reducing appetite, delaying gastric emptying, and decreasing intestinal motility [2-3]. Peptide YY is primarily used in the research of diseases such as obesity, diabetes, and metabolic syndrome [4].
In diet-induced obesity mice model, Continuous administration of Peptide YY (1mg/kg; sc; 7d) can significantly inhibit food intake and induce weight loss, with an average weight loss of approximately 8.3%, showing a stable and sustainable anorectic effect [5]. In C57BLKS/J db/db mice, the combined use of Peptide YY (1mg/kg; sc; 14d) and GLP-1 can significantly increase the glucose infusion rate, enhance the systemic glucose disposal rate, and inhibit hepatic glucose production, thereby improving insulin sensitivity [6].
References:
[1]. Batterham R L, Bloom S R. The gut hormone peptide YY regulates appetite[J]. Annals of the New York Academy of Sciences, 2003, 994(1): 162-168.
[2]. Peptide YY binds to Y2 receptors on the hypothalamus and vagus nerve, inhibiting the release of neuropeptide Y, thereby reducing appetite, delaying gastric emptying, and decreasing intestinal motility
[3]. Wu Y, He H, Cheng Z, et al. The role of neuropeptide Y and peptide YY in the development of obesity via gut-brain axis[J]. Current Protein and Peptide Science, 2019, 20(7): 750-758.
[4]. Lafferty R A, Flatt P R, Irwin N. Emerging therapeutic potential for peptide YY for obesity-diabetes[J]. Peptides, 2018, 100: 269-274.
[5]. Nishizawa N, Niida A, Adachi Y, et al. Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27(16): 3829-3832.
[6]. Boland B B, Laker R C, O'Brien S, et al. Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries[J]. Molecular metabolism, 2022, 55: 101392.
| Animal experiment [1]: | |
Animal models | Diet-induced obesity mice model |
Preparation Method | In this study, the in vivo efficacy and pharmacokinetic characteristics of Peptide YY and its derivative peptides were evaluated in C57BL/6J mice with diet-induced obesity by continuous subcutaneous administration of Peptide YY (1mg/kg/day for 7 days). |
Dosage form | 1mg/kg; sc; 7d |
Applications | Continuous administration of Peptide YY can significantly inhibit food intake and induce weight loss, with an average weight loss of approximately 8.3%, showing a stable and sustainable anorectic effect. |
References: | |
| Cas No. | SDF | ||
| Überlieferungen | Peptide Tyrosine Tyrosine | ||
| Chemical Name | L-tyrosyl-L-prolyl-L-isoleucyl-L-lysyl-L-prolyl-L-α-glutamyl-L-alanyl-L-prolylglycyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-seryl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-asparaginyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-seryl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-leucyl-L-valyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt | ||
| Formula | C194H295N55O57•XCF3COOH | M.Wt | 4309.8 |
| Löslichkeit | Water: 1 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 232 μL | 1.1601 mL | 2.3203 mL |
| 5 mM | 46.4 μL | 232 μL | 464.1 μL |
| 10 mM | 23.2 μL | 116 μL | 232 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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