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Phenserine (Synonyms: (-)-Eseroline phenylcarbamate, (-)-N-Phenylcarbamoyleseroline, (-)-Phenserine)

Katalog-Nr.GC13783

Phenserin ((-)-Eserolinphenylcarbamat) ist ein Derivat von Physostigmin und ist ein potenter, nicht kompetitiver, lang wirkender und selektiver AChE-Hemmer.

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Phenserine Chemische Struktur

Cas No.: 101246-66-6

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5mg
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10mg
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25mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-Phenserine is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.

References:
[1]. al-Jafari AA, et al. Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Biochem Biophys Res Commun. 1998 Jul 9; 248(1):180-5.

Chemical Properties

Cas No. 101246-66-6 SDF
Überlieferungen (-)-Eseroline phenylcarbamate, (-)-N-Phenylcarbamoyleseroline, (-)-Phenserine
Chemical Name (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate
Canonical SMILES O=C(NC1=CC=CC=C1)OC2=CC3=C(C=C2)N(C)[C@H]4N(C)CC[C@]43C
Formula C20H23N3O2 M.Wt 337.42
Löslichkeit DMF: 25 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: 25 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.9637 mL 14.8183 mL 29.6367 mL
5 mM 0.5927 mL 2.9637 mL 5.9273 mL
10 mM 0.2964 mL 1.4818 mL 2.9637 mL
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Berechnen

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Phenserine

Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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