(R)-Bromoenol lactone (Synonyms: (R)BEL) |
| Katalog-Nr.GC40678 |
(R)-Bromenollacton ((R)-BEL) ist ein irreversibler, chiraler, Mechanismus-basierter Inhibitor der Calcium-unabhÄngigen Phospholipase γ (iPLA2γ).
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Cas No.: 478288-90-3
Sample solution is provided at 25 µL, 10mM.
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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM. (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.
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