Bcl-xL
BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.
Produkte für Bcl-xL
- Bestell-Nr. Artikelname Informationen
- GC17512 A-1155463 A-1155463 ist ein hochwirksamer und selektiver BCL-XL-Inhibitor mit einem EC50-Wert von 70 nM in Molt-4-Zellen.
- GC17513 A-1331852 A-1331852 ist ein oral verfÜgbarer selektiver BCL-XL-Inhibitor mit einem Ki von weniger als 10 pM.
- GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins
- GC12139 Gambogic Acid A xanthonoid with anticancer activity
- GC11510 HA14-1 A Bcl-2 inhibitor
- GC12649 TW-37 An inhibitor of the Bcl-2 family proteins
- GC11921 WEHI-539 A selective Bcl-xL inhibitor
- GC13317 WEHI-539 hydrochloride WEHI-539 Hydrochlorid ist ein selektiver Inhibitor von Bcl-XL mit einem IC50 von 1,1 nM.