Vasodilation
Produkte für Vasodilation
- Bestell-Nr. Artikelname Informationen
- GC45602 α-Linolenic Acid-d5 MaxSpec• Standard
- GC40105 βARK1 Inhibitor βARK1-Inhibitor (Methyl-5-[2-(5-nitro-2-furyl)vinyl]-2-furoat) ist ein GRK2 (β-ARK1)-Inhibitor.
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC40386 (±)11(12)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms.
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GC40430
(±)14(15)-EET
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.
- GC41651 (±)14(15)-EET-SI Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes.
- GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.
- GC40436 (±)18-HETE (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid.
- GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively).
- GC40437 (±)5(6)-DiHET lactone 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET.
- GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
- GC40421 (±)8(9)-EE-14(Z)-E (±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries.
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GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC40425 14,15-EE-8(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity.
- GC46438 14S(15R)-EET A cytochrome P450 metabolite of arachidonic acid
- GC40457 19(R)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II.
- GC40503 2-HOBA 2-HOBA (2-HOBA), ein selektiver DicarbonylfÄnger, ist ein Antioxidans und FÄnger von freien Radikalen und Isolevuglandinen (IsoLGs).
- GC41104 20-carboxy Arachidonic Acid 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures.
- GC40336 5-cis Carbaprostacyclin 5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin.
- GC40586 6β-Prostaglandin I1 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions.
- GC18820 6-keto Prostaglandin E1 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.
- GC49576 Abnormal Cannabidiol-d3 Internal standard for the quantification of abnormal cannabidiol
- GC42738 Adrenomedullin (13-52) (human) (trifluoroacetate salt) Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52).
- GC42746 AFP 07 (free acid) Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds.
- GC52023 Alfuzosin-d7 An internal standard for the quantification of alfuzosin
- GC42778 Amauromine Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1 that is selective for CB1 (Ki = 178 nM; Kb = 66.6 nM) over CB2, with no activity at CB2 receptors at concentrations up to 10 μM.
- GC49638 Ambrisentan-d3 An internal standard for the quantification of ambrisentan
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GC46856
Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)
An endogenous angiotensin II fragment
- GC52427 Apelin-12 (human, mouse, rat, bovine) (acetate) An endogenous agonist of the APJ receptor
- GC49314 Arecaidine propargyl ester (hydrobromide) A muscarinic M2 agonist
- GC49057 Azelastine-13C-d3 (hydrochloride) An internal standard for the quantification of azelastine
- GC18313 BAR501 Impurity BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1).
- GC52145 Bradykinin (human, mouse, rat, bovine) (acetate)
- GC49880 Bradykinin (trifluoroacetate salt) An endogenous vasodilator
- GC52424 Bradykinin Fragment (1-5) (trifluoroacetate salt) A metabolite of bradykinin
- GC47045 Carvedilol-d5 An internal standard for the quantification of carvedilol
- GC41381 CAY10562 S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors.
- GC52006 CB-096 An inhibitor of RAN translation
- GC47103 Clonidine-d4 (hydrochloride) An internal standard for the quantification of clonidine
- GC43399 Dehydro Amlodipine (fumarate) Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine.
- GC49866 Desmethyl Carvedilol An active metabolite of carvedilol
- GC46131 Diazoxide-d3 An internal standard for the quantification of diazoxide
- GC49497 Dopamine-d4 (hydrochloride) An internal standard for the quantification of dopamine
- GC47268 Doxazosin-d8 (hydrochloride) An internal standard for the quantification of doxazosin
- GC45761 Flupirtine-d4 (hydrochloride) Flupirtin-d4 (D 9998-d4) Hydrochlorid ist das mit Deuterium bezeichnete Flupirtin.
- GC47371 Fosinopril-d7 (sodium salt) An internal standard for the quantification of fosinopril
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GC49089
FR900359
A cyclic depsipeptide and an inhibitor of Gαq, Gα11, and Gα14
- GC49117 Guanadrel Guanadrel ist ein oral aktiver postganglionÄrer adrenerger Inhibitor von Spiroketal.
- GC47418 Gymnoascolide A A fungal metabolite with fungicidal and vasodilatory activities
- GC43802 HA-1004 (hydrochloride) HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 μM, respectively).
- GC43803 HA-1077 (hydrochloride) Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM fÜr ROCK2 bzw. PKA, PKC, PKG. HA-1077 (Hydrochlorid) ist auch ein potenter Ca2+-Kanalantagonist und Vasodilatator.
- GC49882 Hemokinin 1 (human) (trifluoroacetate salt) A peptide agonist of NK1 receptors
- GC49343 Isoproterenol-d7 (hydrochloride) An internal standard for the quantification of isoproterenol
- GC52310 L-Arginine-13C6 (hydrochloride) An internal standard for the quantification of L-arginine
- GC49374 L-Arginine-d7 (hydrochloride) L-Arginin-d7 ((S)-(+)-Arginin-d7) Hydrochlorid ist das mit Deuterium markierte L-Arginin-Hydrochlorid.
- GC44062 L-hydroxy Arginine (acetate) L-hydroxy Arginine is a substrate for nitric oxide synthase in the catabolism of L-arginine to form nitric oxide.
- GC40239 Limaprost-d3 Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost by GC- or LC-MS.
- GC49916 Lys-(Des-Arg9, Leu8)-Bradykinin (trifluoroacetate salt) A bradykinin B1 receptor antagonist
- GC47679 Minoxidil-d10 An internal standard for the quantification of minoxidil
- GC44320 N-Arachidonoyl-L-Serine Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.
- GC49683 N-desethyl-N-methyl Vardenafil A potential impurity found in commercial preparations of vardenafil
- GC52045 N-desmethyl Azelastine N-Desmethylazelastin ist ein aktiver Hauptmetabolit von Azelastin, der durch das Cytochrom-P450-Enzymsystem mit einer Proteinbindungsrate von 97 % und einer Eliminationshalbwertszeit von 54 Stunden oxidativ metabolisiert wird.
- GC52132 N-desmethyl Diltiazem (hydrochloride)
- GC44351 N-Desmethyl Sildenafil (citrate) N-Desmethyl sildenafil is a major metabolite of sildenafil.
- GC49301 Nesiritide (acetate) A natriuretic peptide
- GC49511 Nicorandil N-oxide A metabolite of nicorandil
- GC49086 Nicorandil-d4 An internal standard for the quantification of nicorandil
- GC47776 Nisoldipine-d6 An internal standard for the quantification of nisoldipine
- GC47824 Olmesartan Medoxomil-d6 Olmesartanmedoxomil-d6 (CS 866-d6) ist das mit Deuterium gekennzeichnete Olmesartanmedoxomil.
- GC49677 Olmesartan-d6 An internal standard for the quantification of olmesartan
- GC44531 PACAP (1-27) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt) Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
- GC44557 PAR2 (1-6) (mouse, rat) PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2.
- GC46202 Phenoxybenzamine-d5 (hydrochloride) Phenoxybenzamin-d5 (Hydrochlorid) ist das mit Deuterium markierte Phenoxybenzamin-Hydrochlorid.
- GC44627 Phenylephrine Glucuronide Phenylephrine glucuronide is a metabolite of the α1A-adrenergic receptor agonist phenylephrine .
- GC44628 Phenylephrine-3-O-Sulfate Phenylephrine-3-O-sulfate is metabolite of the α1A-adrenergic receptor agonist phenylephrine formed via sulfation.
- GC18686 Prazobind Prazobind (SZL 49), ein Prazosin-Analogon, ist ein potenter Alpha-1-Adrenozeptor-Blocker.
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GC18310
Prostaglandin A1
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.
- GC18353 Prostaglandin A2 A naturally occurring prostaglandin with antiviral/antitumor activity
- GC41170 Prostaglandin D2 methyl ester Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.
- GC18768 Prostaglandin E1 ethyl ester Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.
- GC44732 Protopine (hydrochloride) Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.
- GC45903 Quazinone A PDE3 inhibitor
- GC48513 Quinapril-d5 An internal standard for the quantification of quinapril
- GC52034 Quinaprilat Quinaprilat ist ein oral wirksamer Nicht-Mercapto-Hemmer des Angiotensin Converting Enzyme (ACE), des aktiven Metaboliten von Quinapril.
- GC44803 rac-7-hydroxy Propranolol (hydrochloride) rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).
- GC40967 rac-7-methoxy Propranolol Propranolol, one of the first β-blockers used in cardiovascular medicine, inhibits β1-, β2-, and β3-adrenergic receptors with log KD values of -8.16, -9.08, and -6.93, respectively.
- GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
- GC48052 Rilmenidine-d4 An internal standard for the quantification of rilmenidine
- GC49679 Sauvagine (trifluoroacetate salt) A neuropeptide hormone
- GC52460 tcY-NH2 (trifluoroacetate salt) A peptide antagonist of PAR4
- GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
- GC19438 TMB 8 (hydrochloride) TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells.
- GC46233 Trandolaprilat (hydrate) Trandolaprilat (Hydrat) ist ein starker Hemmer des Angiotensin-Converting-Enzyms (ACE).
- GC48202 Treprostinil (diethanolamine salt) Treprostinil (UT-15C) Diethanolamin ist ein potenter EP2-, DP1- und IP-Agonist mit Ki-Werten von 3,6, 4,4, 32,1, 212, 826, 2505 und 4680 nM fÜr EP2, DP1, IP, EP1, EP4, EP3 bzw. FP .
- GC49072 Tribenoside Tribenosid ist ein vasoprotektives Mittel, das fÜr die Erforschung von HÄmorrhoiden verwendet werden kann.
- GC49389 Tritylolmesartan Medoxomil An intermediate in the synthesis of olmesartan medoxomil