CRTH2
CRTh2 (chemoattractant receptor homologous molecule expressed on T-Helper type 2 cells ) is a G-protein coupled receptor for prostaglandin D2. Activation of CRTh2 increases the chemotaxis of Th2 cells/eosinophils/basophil, as well as eosinophil degranulation and Th2 cells cytokine release.
Produkte für CRTH2
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GC12434
AZD1981
AZD1981 ist ein potenter und selektiver CRTh2-Antagonist; verdrÄngt radioaktiv markiertes PGD2 von humanem rekombinantem DP2 mit hoher Potenz (pIC50 = 8,4).
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GC13196
NVP-QAV680
potent and selective CRTh2 receptor antagonist
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