Startseite >> Signaling Pathways >> Immunology/Inflammation

Immunology/Inflammation

The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.

Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases [1]. TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN [2].

BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton’s tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5].

Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase [7]. MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.

Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction [8].

 

References

[1] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.

[2] Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.

[3] Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.

[4] Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.

[5] Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.

[6] Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.

[7] Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.

[8] Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.

Ziele für  Immunology/Inflammation

Produkte für  Immunology/Inflammation

  1. Bestell-Nr. Artikelname Informationen
  2. GC49887 7-(β-Hydroxyethyl)theophylline-d6 An internal standard for the quantification of 7-(β-hydroxyethyl)theophylline 7-(β-Hydroxyethyl)theophylline-d6  Chemical Structure
  3. GC45707 7-Azido-4-methylcoumarin A fluorescent H2S probe 7-Azido-4-methylcoumarin  Chemical Structure
  4. GC40978 7-epi Maresin 1 7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1, which contains a 7(R) hydroxyl group. 7-epi Maresin 1  Chemical Structure
  5. GC49312 7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt) 7-Fluor-2,1,3-benzoxadiazol-4-sulfonat (Ammoniumsalz) ist eine fluoreszierende Markierung. 7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)  Chemical Structure
  6. GC49051 7-hydroxy Methotrexate 7-Hydroxy-Methotrexat ist ein Hauptmetabolit von Methotrexat 7-hydroxy Methotrexate  Chemical Structure
  7. GC42608 7-hydroxy Methotrexate (sodium salt)

    7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.

    7-hydroxy Methotrexate (sodium salt)  Chemical Structure
  8. GC46241 7-keto Cholesterol-d7

    7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL

    7-keto Cholesterol-d7  Chemical Structure
  9. GC48880 7-Methoxyflavone 7-Methoxyflavon ist eine aus Zornia brasiliensis isolierte Verbindung. 7-Methoxyflavone  Chemical Structure
  10. GC13982 7-NINA non-selective NOS inhibitor 7-NINA  Chemical Structure
  11. GC12309 7-Nitroindazole 7-Nitroindazol ist ein selektiver nNOS-Hemmer mit antinozizeptiven und kardiovaskulÄren Wirkungen. 7-Nitroindazole  Chemical Structure
  12. GC42616 7-oxo Staurosporine

    7-oxo Staurosporine is an antibiotic originally isolated from S.

    7-oxo Staurosporine  Chemical Structure
  13. GC52211 7-[1-(1H)-Tetrazolylacetamido]desacetoxycephalosporanic Acid A potential impurity in commercial preparations of cefazolin 7-[1-(1H)-Tetrazolylacetamido]desacetoxycephalosporanic Acid  Chemical Structure
  14. GC41136 8(S),15(S)-DiHETE 8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. 8(S),15(S)-DiHETE  Chemical Structure
  15. GC42623 8-Bromoguanosine 8-Bromoguanosine is a brominated derivative of guanosine. 8-Bromoguanosine  Chemical Structure
  16. GC35199 8-Deoxygartanin 8-Desoxygartanin, ein prenyliertes Xanthon aus G. 8-Deoxygartanin  Chemical Structure
  17. GC42627 8-Hydroxyguanine (hydrochloride) 8-Hydroxyguanine is produced by oxidative degradation of DNA by hydroxyl radical. 8-Hydroxyguanine (hydrochloride)  Chemical Structure
  18. GC18426 8-Nitroguanine 8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents. 8-Nitroguanine  Chemical Structure
  19. GN10212 8-O-Acetyl shanzhiside methyl ester 8-O-Acetyl shanzhiside methyl ester  Chemical Structure
  20. GC49275 8-Oxycoptisine 8-Oxycoptisin ist ein natÜrliches Protoberberin-Alkaloid mit Anti-Krebs-AktivitÄt. 8-Oxycoptisine  Chemical Structure
  21. GC46748 9(E),11(E)-12-nitro Conjugated Linoleic Acid A nitrated fatty acid 9(E),11(E)-12-nitro Conjugated Linoleic Acid  Chemical Structure
  22. GC46749 9(E),11(E)-9-nitro Conjugated Linoleic Acid A nitrated fatty acid 9(E),11(E)-9-nitro Conjugated Linoleic Acid  Chemical Structure
  23. GC42633 9(E)-Erythromycin A oxime (9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin . 9(E)-Erythromycin A oxime  Chemical Structure
  24. GC46753 9(S),12(S),13(S)-TriHOME An oxylipin 9(S),12(S),13(S)-TriHOME  Chemical Structure
  25. GC40324 9(S)-PAHSA 9-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 9(S)-PAHSA  Chemical Structure
  26. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) An isomer of linoleic acid 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)  Chemical Structure
  27. GC42642 9,10-Anthracenediyl-bis(methylene)dimalonic Acid 9,10-Anthracendiyl-bis(methylen)dimalonsÄure (ABMDMA) ist ein biologischer Farbstoff und Indikator, der zum Nachweis der Erzeugung von Singulett-Sauerstoff (SOG) verwendet wird. 9,10-Anthracendiyl-bis(methylen)dimalonsÄure ist ein wasserlÖsliches Derivat von Anthracen. 9,10-Anthracendiyl-bis(methylen)dimalonsÄure kann durch Photobleichen durch Singulett-Sauerstoff zu seinem entsprechenden Endoperoxid gebleicht werden. Diese Reaktion kann spektrophotometrisch Überwacht werden, indem die Abnahme der Extinktion bei 400 nm aufgezeichnet wird. 9,10-Anthracenediyl-bis(methylene)dimalonic Acid  Chemical Structure
  28. GC42644 9-Deazaguanine 9-Deazaguanine is an analog of guanine that acts as an inhibitor of purine nucleoside phosphorylase (PNP; Kd = 160 nM). 9-Deazaguanine  Chemical Structure
  29. GC42648 9-Methylstreptimidone 9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. 9-Methylstreptimidone  Chemical Structure
  30. GC42649 9-Nitrooleate Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. 9-Nitrooleate  Chemical Structure
  31. GC42653 9-OxoOTrE 9-OxoOTrE is produced by the oxidation of 9-HpOTrE. 9-OxoOTrE  Chemical Structure
  32. GC40325 9-PAHSA Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. 9-PAHSA  Chemical Structure
  33. GC49237 93-O17O A cationic lipidoid 93-O17O  Chemical Structure
  34. GC49238 93-O17S A cationic lipidoid 93-O17S  Chemical Structure
  35. GC45960 9c(i472) 9c(i472) ist ein potenter Inhibitor von 15-LOX-1 (15-Lipoxygenase-1) mit einem IC50-Wert von 0,19 μM. 9c(i472)  Chemical Structure
  36. GC45930 A 26771B A macrolide antibiotic A 26771B  Chemical Structure
  37. GC42660 A-39183A A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. A-39183A  Chemical Structure
  38. GC42661 A-54556B A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. A-54556B  Chemical Structure
  39. GC18936 A-83016F A-83016F is an aurodox antibiotic isolated from the actinomycete species A83016. A-83016F  Chemical Structure
  40. GC49309 A-943931 (hydrochloride hydrate) A histamine H4 receptor antagonist A-943931 (hydrochloride hydrate)  Chemical Structure
  41. GC35214 A-9758 A-9758 ist ein RORγ-Ligand und ein potenter, selektiver inverser RORγt-Agonist (IC50=5 nM) und weist eine robuste Wirksamkeit gegen die Freisetzung von IL-17A auf. A-9758  Chemical Structure
  42. GP10060 a-MSH, amide

    a-MSH (α-Melanocortin-stimulierendes Hormon), Amid aktiviert den Melanocortin-1-Rezeptor und aktiviert das zyklische AMP (cAMP) Signal über einen G-Protein-Transporter, kann Melanin synthetisieren.

    a-MSH, amide  Chemical Structure
  43. GC19496 AAPH

    AAPH is a water-soluble azo compound

    AAPH  Chemical Structure
  44. GC42666 AAT-008 AAT-008 ist ein potenter, selektiver und oral aktiver Prostaglandin-EP4-Rezeptorantagonist mit Kis von 0,97 und 6,1 nM fÜr rekombinantes humanes EP4 bzw. rekombinantes Ratten-EP4. AAT-008  Chemical Structure
  45. GC65293 AB-680 AB-680 ist ein hochwirksamer, reversibler und selektiver Inhibitor von CD73 (einer Ecto-Nukleotidase) mit einem Ki von 4,9 pM fÜr hCD73 und einer >10.000-fachen SelektivitÄt gegenÜber verwandten Ecto-Nukleotidasen CD39. Anti-Tumor-AktivitÄt. AB-680  Chemical Structure
  46. GC42667 Abacavir Carboxylate Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir. Abacavir Carboxylate  Chemical Structure
  47. GC46767 Abacavir-d4 An internal standard for the quantification of abacavir Abacavir-d4  Chemical Structure
  48. GC49766 Abafungin Abafungin, ein Antimykotikum, hemmt die Transmethylierung an der C-24-Position der Sterol-Seitenkette, katalysiert durch das Enzym Sterol-C-24-Methyltransferase. Abafungin  Chemical Structure
  49. GC42668 ABC34 ABC34 is an inactive control probe for JJH260, the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34  Chemical Structure
  50. GC49745 ABT-263-d8 ABT-263-d8 ist das Deuterium mit der Bezeichnung Navitoclax. Navitoclax (ABT-263) ist ein potenter und oral aktiver Proteininhibitor der Bcl-2-Familie, der an mehrere anti-apoptotische Proteine der Bcl-2-Familie wie Bcl-xL, Bcl-2 und Bcl-w mit einem Ki von weniger bindet als 1 nM. ABT-263-d8  Chemical Structure
  51. GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp  Chemical Structure
  52. GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)  Chemical Structure
  53. GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)  Chemical Structure
  54. GC42685 Ac-ANW-AMC Ac-ANW-AMC ist ein fluorogenes Substrat fÜr Immunoproteasom. Ac-ANW-AMC  Chemical Structure
  55. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt)  Chemical Structure
  56. GA20621 Ac-muramic acid

    Ein Bestandteil von bakteriellen Zellwänden. Für eine geschützte Derivat von MurNAc siehe Q-1005.

    Ac-muramic acid  Chemical Structure
  57. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2 Ac-VDVAD-AFC (trifluoroacetate salt)  Chemical Structure
  58. GC15598 Ac2-26 Ac2-26, ein aktives N-terminales Peptid von Annexin A1 (AnxA1), dÄmpft eine durch IschÄmie-Reperfusion induzierte akute LungenschÄdigung. Ac2-26  Chemical Structure
  59. GC49263 Ac2-26 (human) (ammonium salt) An annexin A1-mimetic peptide Ac2-26 (human) (ammonium salt)  Chemical Structure
  60. GC35224 Ac2-26 TFA Ac2-26 TFA, ein aktives N-terminales Peptid von Annexin A1 (AnxA1), schwÄcht eine durch IschÄmie-Reperfusion induzierte akute LungenschÄdigung ab. Ac2-26 TFA  Chemical Structure
  61. GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac Aceclofenac ethyl ester  Chemical Structure
  62. GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac Aceclofenac methyl ester  Chemical Structure
  63. GC49911 Acetyl Hexapeptide-38 (trifluoroacetate salt) A hexapeptide Acetyl Hexapeptide-38 (trifluoroacetate salt)  Chemical Structure
  64. GC42700 Acetyl Pentapeptide-1 Acetyl pentapeptide-1 is a pentapeptide that decreases IL-8 secretion in human keratinocytes when used in combination with acetyl hexapeptide-36 and acetyl hexapeptide-38. Acetyl Pentapeptide-1  Chemical Structure
  65. GC18443 Acetyl-6-formylpterin Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation. Acetyl-6-formylpterin  Chemical Structure
  66. GC11786 Acetylcysteine

    Acetylcystein ist das N-Acetyl-Derivat von CYSTEIN.

    Acetylcysteine  Chemical Structure
  67. GC17416 ACHP IκB kinase inhibitor ACHP  Chemical Structure
  68. GN10536 Aconine Aconine  Chemical Structure
  69. GC49804 Acridine An azaarene Acridine  Chemical Structure
  70. GC40645 Actarit Actarit, ein oral aktiver antirheumatischer Wirkstoff, hat das Potenzial, durch Kollagen Typ II verursachte Arthritis zu behandeln. Actarit  Chemical Structure
  71. GC41316 Actinopyrone A Actinopyrone A is a pyrone isolated from S. Actinopyrone A  Chemical Structure
  72. GC48842 Actiphenol A bacterial metabolite with antiviral activity Actiphenol  Chemical Structure
  73. GC46797 Acyclovir-d4 An internal standard for the quantification of acyclovir Acyclovir-d4  Chemical Structure
  74. GC46798 Adapalene-d3 An internal standard for the quantification of adapalene Adapalene-d3  Chemical Structure
  75. GC46805 Adefovir-d4 An internal standard for the quantification of adefovir Adefovir-d4  Chemical Structure
  76. GC31693 Adelmidrol Adelmidrol Übt wichtige entzÜndungshemmende Wirkungen aus, die teilweise von PPARγ abhÄngig sind. Adelmidrol  Chemical Structure
  77. GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase Adenosine 5’-methylenediphosphate (hydrate)  Chemical Structure
  78. GC60040 ADH-503 ADH-503 ((Z)-Leukadherin-1-Cholin) ist ein oral aktiver und allosterischer CD11b-Agonist. ADH-503 fÜhrt zur Repolarisation tumorassoziierter Makrophagen, zur Verringerung der Anzahl tumorinfiltrierender immunsuppressiver myeloischer Zellen und verstÄrkt die Reaktionen dendritischer Zellen. ADH-503  Chemical Structure
  79. GC42742 ADT-OH ADT-OH ist ein Schwefelwasserstoff freisetzender Donor. ADT-OH induziert Apoptose und hemmt die Entwicklung von Melanomen in vivo durch Hochregulierung von FADD. ADT-OH hat das Potenzial fÜr die Erforschung von Krebserkrankungen. ADT-OH  Chemical Structure
  80. GC31649 ADU-S100 (ML RR-S2 CDA) ADU-S100 (ML RR-S2 CDA) (MIW815), ein Aktivator des Stimulators von Interferon-Genen (STING), fÜhrt zu einer potenten und systemischen Tumorregression und ImmunitÄt. ADU-S100 (ML RR-S2 CDA)  Chemical Structure
  81. GC39161 ADU-S100 disodium salt ADU-S100 Dinatriumsalz (MIW815 Dinatriumsalz) ist ein Aktivator des Stimulators von Interferon-Genen (STING). ADU-S100 disodium salt  Chemical Structure
  82. GC42743 AEM1 AEM1 ist ein Nrf2-Inhibitor. AEM1 reduziert die Expression von Nrf2-abhÄngigen Genen in A549-Zellen und hemmt das Wachstum von A549-Zellen in vitro und in vivo. AEM1  Chemical Structure
  83. GC63485 Afimetoran Afimetoran ist ein Toll-like-Rezeptorantagonist, der in der Erforschung von EntzÜndungs- und Autoimmunerkrankungen eingesetzt werden kann. Afimetoran  Chemical Structure
  84. GC66396 Agatolimod Agatolimod (ODN 2006), ein ODN (Oligodesoxynukleotid) der Klasse B, ist ein TLR9-Agonist. Auch fÜr den Menschen ist Agatolimod eine optimale CpG-Sequenz. Agatolimod stimuliert eine sehr starke Produktion von NO2 und IL-6 in HD11-Zellen. Agatolimod kann fÜr die Brustkrebsforschung verwendet werden. Sequenz: 5&7#39;-tcgtcgttttgtcgttttgtcgtt-3&7#39;. Agatolimod  Chemical Structure
  85. GC16831 Agmatine sulfate Agmatinsulfat Übt eine modulierende Wirkung auf mehrere molekulare Ziele wie Neurotransmittersysteme, IonenkanÄle und die Stickoxidsynthese aus. Agmatine sulfate  Chemical Structure
  86. GC35271 AHR antagonist 1 AHR-Antagonist 1 (AHR-Antagonist 1) ist ein Aryl-Kohlenwasserstoff-Rezeptor (AHR)-Antagonist. AHR antagonist 1  Chemical Structure
  87. GC39669 AHR antagonist 2 AHR-Antagonist 2 ist ein potenter Arylkohlenwasserstoffrezeptor (AHR)-Antagonist, extrahiert aus Patent WO2019101641A1, Verbindungsbeispiel 1, mit IC50-Werten von 0,885 und 2,03 nM fÜr Human- und Maus-AhR. AHR antagonist 2  Chemical Structure
  88. GC64275 AHR antagonist 5 AHR-Antagonist 5, ein potenter und oral aktiver Arylhydrocarbonrezeptor (AHR)-Antagonist, extrahiert aus Patent WO2018195397, Beispiel 39, hat einen IC50 von < 0,5 μμ. AHR-Antagonist 5 hemmt signifikant das Tumorwachstum in Kombination mit dem Checkpoint-Inhibitor Anti-PD-1. AHR antagonist 5  Chemical Structure
  89. GC64208 AHR antagonist 5 free base Die freie Base des AHR-Antagonisten 5 ist ein selektiver und oral aktiver Arylhydrocarbonrezeptor (AHR)-Inhibitor. Die freie Base des AHR-Antagonisten 5 blockiert wirksam die Translokation von AHR aus dem Zytoplasma in den Zellkern. Die freie Base des AHR-Antagonisten 5 ist hochgradig selektiv fÜr AHR gegenÜber anderen Rezeptoren, Transportern und Kinasen. AHR antagonist 5 free base  Chemical Structure
  90. GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor AI-3  Chemical Structure
  91. GC46821 Ajoene Ajoene, eine aus Knoblauch gewonnene Verbindung, ist ein antithrombotisches und antimykotisches Mittel. Ajoene  Chemical Structure
  92. GC45681 AKP-11 An S1P1 receptor agonist AKP-11  Chemical Structure
  93. GC42763 Alamethicin F50 Alamethicin F50 is a peptaibol isolated from Trichoderma. Alamethicin F50  Chemical Structure
  94. GC49773 Albendazole sulfone-d3 An internal standard for the quantification of albendazole sulfone Albendazole sulfone-d3  Chemical Structure
  95. GC48848 Albendazole-d7 Albendazol-d7 (SKF-62979-d7) ist das mit Deuterium markierte Albendazol. Albendazole-d7  Chemical Structure
  96. GC41080 Albofungin Albofungin is a xanthone isolated from A. Albofungin  Chemical Structure
  97. GC42764 Albuterol methyl ether Salbutamol (albuterol) is a selective β2-adrenergic partial agonist that is used as a bronchodilator. Albuterol methyl ether  Chemical Structure
  98. GC46826 Alclofenac An NSAID Alclofenac  Chemical Structure
  99. GC40638 Alclometasone Dipropionate Alclometasondipropionat (Sch 22219) ist eine Steroidverbindung. Alclometasone Dipropionate  Chemical Structure
  100. GN10298 Alibiflorin Alibiflorin  Chemical Structure
  101. GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. all-trans Retinoyl β-D-Glucuronide  Chemical Structure

Artikel 401 bis 500 von 2909 gesamt

pro Seite
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7

Absteigend sortieren