DHFR
Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
Produkte für DHFR
- Bestell-Nr. Artikelname Informationen
- GC16333 Cycloguanil (hydrochloride) Cycloguanil (Hydrochlorid), der aktive Metabolit von Proguanil, wirkt auf Malaria-Schizonten in Erythrozyten und Hepatozyten.
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GC10405
Methotrexate
Methotrexat, ein Folsäureantagonist, ist ein wirksames entzündungshemmendes Mittel, wenn es wöchentlich in niedrigen Konzentrationen angewendet wird. Die antiphlogistische Wirkung beruht auf einer erhöhten Freisetzung von Adenosin an entzündeten Stellen.
- GC11610 Pemetrexed An antifolate with anticancer activity
- GC17694 Pemetrexed disodium hemipenta hydrate
- GC12919 Pralatrexate A dihydrofolate reductase inhibitor
- GC17867 Pyrimethamine A dihydrofolate reductase inhibitor