Startseite >> Signaling Pathways >> Metabolism >> DHFR

DHFR

Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.

Produkte für  DHFR

  1. Bestell-Nr. Artikelname Informationen
  2. GC16333 Cycloguanil (hydrochloride) Cycloguanil (Hydrochlorid), der aktive Metabolit von Proguanil, wirkt auf Malaria-Schizonten in Erythrozyten und Hepatozyten. Cycloguanil (hydrochloride)  Chemical Structure
  3. GC10405 Methotrexate

    Methotrexat, ein Folsäureantagonist, ist ein wirksames entzündungshemmendes Mittel, wenn es wöchentlich in niedrigen Konzentrationen angewendet wird. Die antiphlogistische Wirkung beruht auf einer erhöhten Freisetzung von Adenosin an entzündeten Stellen.

    Methotrexate  Chemical Structure
  4. GC11610 Pemetrexed An antifolate with anticancer activity Pemetrexed  Chemical Structure
  5. GC17694 Pemetrexed disodium hemipenta hydrate Pemetrexed disodium hemipenta hydrate  Chemical Structure
  6. GC12919 Pralatrexate A dihydrofolate reductase inhibitor Pralatrexate  Chemical Structure
  7. GC17867 Pyrimethamine A dihydrofolate reductase inhibitor Pyrimethamine  Chemical Structure

6 Artikel

pro Seite

Absteigend sortieren