MAO
Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine. Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.
Produkte für MAO
- Bestell-Nr. Artikelname Informationen
- GC14122 Clorgyline (hydrochloride) Clorgylin (Hydrochlorid) ist ein irreversibler und selektiver Hemmer der Monoaminoxidase A (MAO-A), der in der wissenschaftlichen Forschung verwendet wird; strukturell verwandt mit Pargyline.
- GC12962 Isatin Isatin (Indolin-2,3-dion) ist ein potenter Inhibitor der Monoaminoxidase (MAO) mit einem IC50 von 3 μM.
- GC11703 Moclobemide (Ro 111163) An Analytical Reference Standard
- GC16824 Pargyline (hydrochloride) Pargylin (Hydrochlorid) ist ein irreversibler Monoaminoxidase (MAO)-Hemmer mit einem Kis von 13 μM und 0,5 μM für MAO-A bzw. MAO-B.
- GC12801 Rasagiline Mesylate An inhibitor of MAO-B
- GC14673 Safinamide Mesylate An inhibitor of MAO-B