Transferase
Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.
Produkte für Transferase
- Bestell-Nr. Artikelname Informationen
- GC15614 A922500 A diacylglycerol acyltransferase 1 inhibitor
- GC10905 Amodiaquine dihydrochloride dihydrate Amodiaquin-Dihydrochlorid-Dihydrat (Amodiaquin-Dihydrochlorid-Dihydrat), eine 4-Aminochinolin-Klasse von Antimalariamitteln, ist ein starker und oral aktiver Histamin-N-Methyltransferase-Inhibitor.
- GC12912 BCATc Inhibitor 2 BCATc Inhibitor 2 ist ein selektiver Inhibitor der verzweigtkettigen Aminotransferase (BCAT) zur Erforschung neurodegenerativer Erkrankungen.
- GC11524 Cystamine dihydrochloride transglutaminase inhibitor
- GC14308 FK866 (APO866) Inhibitor of nicotinamide phosphoribosyltransferase
- GC17780 FTase Inhibitor II Ftase inhibitor
- GC16310 FTI 277 HCl FTI 277 HCl ist ein Inhibitor der Farnesyltransferase (FTase); ein hochpotentes Ras-CAAX-Peptidomimetikum, das sowohl die onkogene H- als auch die K-Ras-Signalgebung antagonisiert.
-
GC16612
GGsTop
γ-Glutamyl-Transpeptidase (GGT)-Inhibitor, neuartig und irreversibel.
-
GC11884
GPP 78 hydrochloride
NAMPT inhibitor
- GC10170 LB42708 LB42708 ist ein potenter, selektiver und oral aktiver Farnesyltransferase-Inhibitor.
- GC10330 Lonafarnib A farnesyltransferase inhibitor with antitumor activity
- GC16129 LY 78335 phenylethanolamine-N-methyltransferase (PNMT) inhibitor
- GC10265 Manumycin A Manumycin A ist ein Antibiotikum.
- GC10106 OR-486 OR-486 (OR-486) ist ein potenter Catechol-O-Methyltransferase-Inhibitor mit einem IC50 von 12 nM.
- GC12981 OU749 γ-Glutamyl transferase (GGT) inhibitor
- GC15274 PF-04620110 A potent, bioavailable inhibitor of DGAT-1
- GC12449 SKF 91488 dihydrochloride histamine N-methyltransferase inhibitor
- GC15442 Tipifarnib (Zarnestra) A farnesyltransferase inhibitor with antitumor activity
- GC17921 Tolcapone A reversible COMT inhibitor
- GC17046 Tris DBA N-myristoyltransferase-1 (NMT-1) inhibitor
-
GC16738
Tunicamycin Mixture
Antibiotikum, hemmt GlcNAc-Phosphotransferase (GPT)