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Calpains

Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).

Produkte für  Calpains

  1. Bestell-Nr. Artikelname Informationen
  2. GC12152 Acetyl-Calpastatin (184-210) (human) Acetyl-Calpastatin (184-210) (human)  Chemical Structure
  3. GC12527 Calpain Inhibitor I, ALLN A non-selective cysteine protease inhibitor Calpain Inhibitor I, ALLN  Chemical Structure
  4. GC16383 Calpain Inhibitor II, ALLM Calpain inhibitor Calpain Inhibitor II, ALLM  Chemical Structure
  5. GC12479 Calpain Inhibitor XII Calpain Inhibitor XII ist ein reversibler und selektiver Inhibitor von Calpain I (μ-Calpain, Ki=19 nM). Calpain Inhibitor XII  Chemical Structure
  6. GC10342 Calpeptin A calpain inhibitor Calpeptin  Chemical Structure
  7. GC13418 E-64

    Ein Pilzmetabolit mit vielfältigen biologischen Aktivitäten.

    E-64  Chemical Structure
  8. GC11640 MDL 28170 A cell permeable, selective calpain inhibitor MDL 28170  Chemical Structure
  9. GC10383 MG-132

    Ein potenter Proteasom-Inhibitor

    MG-132  Chemical Structure
  10. GC13450 PD 145305 selective inhibitor of calpains PD 145305  Chemical Structure
  11. GC16912 PD 150606 An inhibitor of calpains PD 150606  Chemical Structure
  12. GC15066 Z-FA-FMK An inhibitor of cysteine proteases, including cathepsin B Z-FA-FMK  Chemical Structure

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