Lipoxygenase
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Ziele für Lipoxygenase
Produkte für Lipoxygenase
- Bestell-Nr. Artikelname Informationen
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GC38000
β-Boswellic acid
- Boswelliasäure wird aus dem Gummiharz von Boswellia serrate isoliert . β-Boswelliasäure hemmt die Synthese von DNA, RNA und Protein in menschlichen Leukämie-HL-60-Zellen.
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GC48738
(±)12-HETE-d8
(±)12-Hydroxyeicosatetraenoic Acid-d8
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GC41649
(±)13-HODE cholesteryl ester
(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
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GC48739
(±)15-HETE-d8
(±)15-Hydroxyeicosatetraenoic Acid-d8
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GC40828
(±)5-HETE lactone
(±)5-Hydroxyeicosatetraenoic Acid lactone
(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. -
GC41666
(±)9-HODE cholesteryl ester
(±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
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GC90533
(-)-Pinoresinol
Ein Lignan mit vielfältigen biologischen Aktivitäten.
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GC41770
1,2,3-Trieicosapentaenoyl-rac-glycerol
EPA-TG, Glycerol Trieicosapentaenoate, TG(20:5/20:5/20:5)
1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid, which is an ω-3 fatty acid. -
GC45948
1,2,3-Trilinoelaidoyl-rac-glycerol
TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E)), Trilinoelaidin
A triacylglycerol -
GC42039
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. -
GC42040
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. -
GC49730
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11
15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE -
GC42041
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. -
GC42042
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. -
GC40971
10(S),17(S)-DiHDHA
10(S),17(S)-DiHDoHE, PDX, Protectin DX
10(S),17(S)-DiHDHA (auch als Neuroprotectin D1 bekannt, wenn es in neuronalen Geweben produziert wird) ist eine von DHA abgeleitete DihydroxyfettsÄure, die starke schÜtzende und entzÜndungshemmende AktivitÄten aufweist. -
GC40368
11(R)-HEPE
11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO.
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GC40445
11(R)-HETE
11(R)-Hydroxyeicosatetraenoic Acid
11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. -
GC10821
11-keto-β-Boswellic Acid
11-oxo-β-Boswellic acid,KBA
11-Keto-beta-BoswelliasÄure (11-Keto-β-BoswelliasÄure) ist eine pentazyklische TriterpensÄure des Oleogumharzes aus der Rinde des Boswellia-Serratbaums, im Volksmund bekannt als Indischer Weihrauch. Die entzÜndungshemmende Wirkung von 11-Keto-beta-BoswelliasÄure beruht hauptsÄchlich auf der Hemmung der 5-Lipoxygenase (5-LOX) und der anschließenden Leukotrien- und Kernfaktor-Kappa-B-Aktivierung (NF-&7#954;B) und der Bildung des Tumor-Nekrose-Faktors Alpha Produktion. -
GC41144
11-trans Leukotriene C4
11trans LTC4
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. -
GC41147
11-trans Leukotriene D4
11trans LTD4
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. -
GC41149
11-trans Leukotriene E4
11trans LTE4
11-trans-Leukotrien E4 ist ein Isomer von Leukotrien E4 (LTE4). -
GC40447
12(R)-HETE
12(R)-Hydroxyeicosatetraenoic Acid
Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid. -
GC40371
12(S)-HEPE
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO.
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GC40448
12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
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GC40449
12(S)-HETE MaxSpec® Standard
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
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GC40349
12(S)-HETE-19,20-alkyne
Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. -
GC41882
12(S)-HETrE
12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).
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GC41095
12(S)-HpEPE
12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid.
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GC41122
12(S)-HpETE
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.
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GC41123
12-epi Leukotriene B4
12epi LTB4
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. -
GC46416
12-epi Leukotriene B4-d4
12epi LTB4d4
A neuropeptide with diverse biological activities -
GC41096
12-oxo Leukotriene B4
12keto LTB4, 12oxo LTB4
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. -
GC46418
12-oxo-13-HOME
An oxylipin
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GC90652
12-oxo-9(Z)-Dodecenoic Acid
Ein Metabolit von Linolsäure und Linolensäure.
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GC40372
12-OxoETE
12KETE
12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. -
GC19462
13(R)-HODE
13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase.
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GC19463
13(S)-HODE
13(S)-HODE
13(S)-HODE (13(S)-HODE), das Produkt des 15-Lipoxygenase (15-LOX)-Metabolismus von LinolsÄure, fungiert als endogener Ligand zur Aktivierung von PPARγ. -
GC41220
13(S)-HODE methyl ester
13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells.
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GC41896
13(S)-HODE-biotin
13(S)-HODE is the lipoxygenase metabolite of linoleic acid.
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GC46420
13(S)-HODE-d4
An internal standard for the quantification of 13-HODE
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GC41897
13(S)-HOTrE
13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.
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GC41898
13(S)-HOTrE(γ)
13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid.
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GC19474
13(S)-HpODE
13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals.
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GC41899
13(S)-HpOTrE
13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.
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GC41900
13(S)-HpOTrE(γ)
13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.
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GC41911
13-epi-12-oxo Phytodienoic Acid
13epi12oxo PDA
13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. -
GC46436
13-OxoODE-d3
13KODEd3
A neuropeptide with diverse biological activities -
GC41206
14(S)-HDHA
14(S)-hydroxy Docosahexaenoic Acid, 14(S)-HDoHE
14(S)-HDHA (14(S)-HDoHE) ist ein Oxygenierungsprodukt der DocosahexaensÄure (DHA). -
GC41100
14,15-dehydro Leukotriene B4
14,15dehydro LTB4
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. -
GC41145
14,15-Leukotriene C4
Eoxin C4, EXC4, 14,15LTC4
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. -
GC41148
14,15-Leukotriene D4
Eoxin D4, EXD4, 14,15-LTD4
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. -
GC41150
14,15-Leukotriene E4
Eoxin E4, EXE4, 14,15LTE4
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. -
GC41415
15(R)-Lipoxin A4
AT-Lipoxin A4
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function.
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GC40427
15(S)-HEDE
15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO.
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GC40373
15(S)-HEPE
15S-hydroxy-Eicosapentaenoic Acid
15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. -
GC40374
15(S)-HEPE MaxSpec® Standard
15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO.
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GC46441
15(S)-HEPE-d5
15S-Hydroxyeicosapentaenoic Acid-d5
A neuropeptide with diverse biological activities -
GC40451
15(S)-HETE
15(S)-Hydroxyeicosatetraenoic Acid
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. -
GC41925
15(S)-HETE Ethanolamide
15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide
Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC. -
GC40452
15(S)-HETE MaxSpec® Standard
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
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GC40839
15(S)-HETE methyl ester
15(S)-Hydroxyeicosatetraenoic Acid methyl ester
15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. -
GC41926
15(S)-HETE-biotin
15(S)-Hydroxyeicosatetraenoic Acid-biotin
15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. -
GC46442
15(S)-HETE-d8
15(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15-HETE -
GC49894
15(S)-HETE-d8 ethyl ester
15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester
An internal standard for the quantification of 15(S)-HETE ethyl ester -
GC41927
15(S)-HETrE
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid.
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GC41403
15(S)-HpEDE
15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid.
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GC41101
15(S)-HpEPE
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid.
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GC41124
15(S)-HpETE
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid.
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GC41938
15-Lipoxygenase Inhibitor 1
15LO Inhibitor 1
15-Lipoxygenase-Inhibitor 1 ist ein selektiver Inhibitor der 15-Lipoxygenase mit einem IC50-Wert von 18 μM. 15-Lipoxygenase-Inhibitor 1 hat IC50s von 19,5 μM und 19,1 ⋼M fÜr Sojabohnen-15-Lipoxygenase (SLO) bzw. menschliche 15-Lipoxygenase-1 (15-LOX-1). 15-Lipoxygenase Inhibitor 1 hat Potenzial fÜr die Erforschung von Prostatakrebs. -
GC41940
15-OxoEDE
15KEDE
15-OxoEDE is produced by the oxidation of 15-HEDE. -
GC40376
15-OxoETE
15KETE
15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. -
GC41951
17(R)-Resolvin D1
Aspirin-triggered Resolvin D1
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
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GC41227
17(R)-Resolvin D1 methyl ester
AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester
17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). -
GC46457
17(R)-Resolvin D1-d5
Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5
A neuropeptide with diverse biological activities -
GC41952
17(R)-Resolvin D4
4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 . -
GC41208
17(S)-HDHA
17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE
17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. -
GC46048
17(S)-HDHA-d5
17(S)-hydroxy Docosahexaenoic Acid-d5, 17(S)-HDoHE-d5
A neuropeptide with diverse biological activities -
GC49356
17(S)-HDoTE
17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid
A metabolite of adrenic acid -
GC40975
17(S)-HpDHA
17(S)hydroperoxy Docosahexaenoic Acid, 17(S)HpDoHE
17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. -
GC41529
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
EFOX, 17oxo4(Z),7(Z),10(Z),13(Z),15(E),19(Z)DHA, 17-oxo-DHA
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. -
GC41209
17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
EFOX, 17-oxo-DPA, 17oxo7(Z),10(Z),13(Z),15(E),19(Z)DPA
Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. -
GC41980
18-carboxy dinor Leukotriene B4
18carboxy dinor LTB4
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. -
GC46057
2,5-Dihydroxycinnamic Acid phenethyl ester
An inhibitor of 5-LO
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GC42082
20-carboxy Leukotriene B4
20carboxy LTB4
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. -
GC41421
20-hydroxy Leukotriene B4
20hydroxy LTB4
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. -
GC49849
3-Aminosalicylic Acid
3-ASA, NSC 285111
A salicylic acid derivative -
GC49364
3-Hydroxycoumarin
3-Coumarinol, NSC 74691
3-Hydroxycumarin ist ein starker Redox-Inhibitor von menschlichem 15-LOX-1. -
GC64078
3-O-Acetyl-11-hydroxy-beta-boswellic acid
3-O-Acetyl-11-hydroxy-beta-BoswelliasÄure ist ein potenter Inhibitor der 5-Lipoxygenase (5-LO).
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GC30277
4',5-Dihydroxyflavone
4',5-Dihydroxyflavon ist ein Sojabohnen-LOX-1- und Hefe-α-Glucosidase-Inhibitor mit einem Ki von 102,6 μM fÜr Sojabohnen-LOX-1 und einem IC50 von 66 μM fÜr Hefe-α-Glucosidase.
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GC45931
4(S),11(R)-DiHDoHE
A neuropeptide with diverse biological activities
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GC64621
4-Nitrocatechol
4-Nitrocatechol ist ein potenter Lipoxygenase-Hemmer.
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GC40459
5(R)-HETE
5(R)-Hydroxyeicosatetraenoic Acid
5(R)-HETE is a rare lipoxygenase product of arachidonic acid. -
GC41126
5(S),12(S)-DiHETE
5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid.
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GC41127
5(S),15(S)-DiHETE
5(S),15(S)-DiHETE ist ein „aktiviertes“ Intermediat, hemmt die Thrombozytenaggregation mit einem IC50 von 1,3 μM.
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GC41128
5(S),6(R)-11-trans DiHETE
5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor.
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GC41129
5(S),6(R)-DiHETE
5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4).
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GC41131
5(S),6(S)-DiHETE
5(S),6(S)-DiHETE is one of the four diastereomeric 5,6-dihydroxy acids produced from the non-enzymatic hydrolysis of LTA4.
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GC40378
5(S)-HEPE
5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA).
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GC40379
5(S)-HEPE MaxSpec® Standard
5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA).
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GC40460
5(S)-HETE
5(S)-Hydroxyeicosatetraenoic Acid
5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide.