Ricinine (Synonyms: NSC 409913, NSC 642604) |
| Katalog-Nr.GC49485 |
Ricinin zeigt Leberschutz bei CCl4-induzierten LeberschÄden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 524-40-3
Sample solution is provided at 25 µL, 10mM.
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Ricinine is a piperidine alkaloid that has been found in R. communis and has diverse biological activities.1,2,3,4 It is an inhibitor of acetylcholinesterase (AChE; IC50 = 54.5 µg/ml).2 It scavenges ABTS radicals and chelates iron (IC50s = 102.65 and 104.32 µg/ml, respectively). Ricinine is toxic to adult A. gambiae when used at a concentration of 0.04 mg/ml in a feeding assay.3 It is also toxic to mice with an intraperitoneal LD50 value of 340 mg/kg but an oral LD50 value of 3,000 mg/kg.1 It has been used as a biomarker of ricin poisoning.4
1.Franke, H., Scholl, R., and Aigner, A.Ricin and Ricinus communis in pharmacology and toxicology-from ancient use and "Papyrus Ebers" to modern perspectives and "poisonous plant of the year 2018"Naunyn Schmiedebergs Arch. Pharmacol.392(10)1181-1208(2019) 2.Khan, B.R., Ghous, T., Rasheed, A., et al.Evaluation of anti-acetylcholinesterase activity and antioxidant potential of ricinine (a central nervous system stimulant) isolated from Ricinius communis L.J. Chem. Soc. Pak.38(2)326-332(2016) 3.Wachira, S.W., Omar, S., Jacob, J.W., et al.Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiaeParasit. Vectors7312(2014) 4.Johnson, R.C., Lemire, S.W., Woolfitt, A.R., et al.Quantification of ricinine in rat and human urine: A biomarker for ricin exposureJ. Anal. Toxicol.29(3)149-155(2005)
| Cas No. | 524-40-3 | SDF | |
| Überlieferungen | NSC 409913, NSC 642604 | ||
| Canonical SMILES | N#CC1=C(C=CN(C)C1=O)OC | ||
| Formula | C8H8N2O2 | M.Wt | 164.2 |
| Löslichkeit | DMSO: slightly soluble,Methanol: slightly soluble | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.0901 mL | 30.4507 mL | 60.9013 mL |
| 5 mM | 1.218 mL | 6.0901 mL | 12.1803 mL |
| 10 mM | 0.609 mL | 3.0451 mL | 6.0901 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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