SGC-iMLLT |
| Katalog-Nr.GC34778 |
SGC-iMLLT ist eine erstklassige chemische Sonde und ein potenter, selektiver Inhibitor von MLLT1/3-Histon-Wechselwirkungen mit einem IC50 von 0,26 μM. SGC-iMLLT zeigt eine hohe BindungsaktivitÄt gegenÜber der MLLT1-YEATS-DomÄne (YD) und MLLT3-YD (AF9/YEATS3) mit Kds von 0,129 bzw. 0,077 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2255338-25-9
Sample solution is provided at 25 µL, 10mM.
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SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1]. IC50: 0.26 μM (MLLT1 YD)[1]Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]
[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.
| Cas No. | 2255338-25-9 | SDF | |
| Canonical SMILES | CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[C@@H](C)CCC4)=N5)C5=C3)=O)=CC=C21 | ||
| Formula | C22H24N6O | M.Wt | 388.47 |
| Löslichkeit | DMSO : 83.33 mg/mL (214.51 mM);Water : < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5742 mL | 12.871 mL | 25.742 mL |
| 5 mM | 514.8 μL | 2.5742 mL | 5.1484 mL |
| 10 mM | 257.4 μL | 1.2871 mL | 2.5742 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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