STAT3 Inhibitor 4m (Synonyms: Signal Transducer and Activator of Transcription 3 Inhibitor 4m) |
| Katalog-Nr.GC52293 |
A STAT3 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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STAT3 inhibitor 4m is an inhibitor of STAT3 and a derivative of celastrol .1 It inhibits the phosphorylation of STAT3 and decreases levels of the STAT3 target proteins survivin and myeloid cell leukemia 1 (Mcl-1) in HCT116 cells when used at concentrations of 0.75 and 1 µM. STAT3 inhibitor 4m inhibits the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively). It induces apoptosis and cell cycle arrest at both the S and G2/M phases in HCT116 cells when used at a concentration of 5 µM. STAT3 inhibitor 4m (1-10 µM) also reduces the viability of human colorectal cancer organoids (CCOs).
1.Xu, S., Fan, R., Wang, L., et al.Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibitionJ. Enzyme Inhib. Med. Chem.37(1)236-251(2022)
| Cas No. | SDF | ||
| Überlieferungen | Signal Transducer and Activator of Transcription 3 Inhibitor 4m | ||
| Canonical SMILES | O=C(NCCC1=CC=CS1)[C@]2(C)CC[C@]3(C)CC[C@]4(C)C([C@@]5(C)CC[C@@]4(C)[C@]3([H])C2)=CC=C(C5=C6)C(C)=C(O)C6=O | ||
| Formula | C35H45NO3S | M.Wt | 559.8 |
| Löslichkeit | Chloroform: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7864 mL | 8.9318 mL | 17.8635 mL |
| 5 mM | 0.3573 mL | 1.7864 mL | 3.5727 mL |
| 10 mM | 0.1786 mL | 0.8932 mL | 1.7864 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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