trans-Chalcone |
| Katalog-Nr.GC61896 |
trans-Chalcone, isoliert aus der Haut von Aronia melanocarpa, ist eine biphenolische Kernstruktur von FlavonoidvorlÄufern.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 614-47-1
Sample solution is provided at 25 µL, 10mM.
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trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].
trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 µM[2]. trans-Chalcone (30.23-98.03 µM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells[1]. trans-Chalcone (20-80 µM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2[1]. trans-Chalcone (58.25 µM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours[1]. trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20=30.23 µM; IC50=58.25 µM; IC80=98.03 µM). trans-Chalcone (48 h) has IC50s of 41.53 µM and 48.41 µM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity[1].
References:
[1]. Luis Felipe Buso Bortolotto, et al. Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Biomed Pharmacother. 2017 Jan;85:425-433.
[2]. Mahmoud Najafian, et al. Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase. Mol Biol Rep. 2011 Mar;38(3):1617-20.
[3]. Tamires Aparecida Bitencourt, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229.
| Cas No. | 614-47-1 | SDF | |
| Canonical SMILES | O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2 | ||
| Formula | C15H12O | M.Wt | 208.26 |
| Löslichkeit | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.8017 mL | 24.0085 mL | 48.0169 mL |
| 5 mM | 0.9603 mL | 4.8017 mL | 9.6034 mL |
| 10 mM | 0.4802 mL | 2.4008 mL | 4.8017 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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