TSHR antagonist S37 |
| Katalog-Nr.GC26016 |
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1217616-61-9
Sample solution is provided at 25 µL, 10mM.
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TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
TSHR antagonist S37 not only inhibits the thyrotropin receptor (TSHR) activation by thyrotropin itself but also activation by monoclonal TSAb M22 (human), KSAb1 (murine), and the allosteric small-molecule agonist C2. Disease-related ex vivo studies in HEK 293 cells expressing the TSHR shows that TSHR antagonist S37 also inhibits cyclic adenosine monophosphate formation by oligoclonal thyroid stimulating antibodies (TSAb).[1]
TSHR antagonist S37 has no toxicity and a remarkable 53% oral bioavailability in mice, indicating by initial in vivo pharmacokinetic studies.[1];
[1] Neumann S, et al. Eur Thyroid J. 2020 Dec;9(Suppl 1):59-65.
| Cas No. | 1217616-61-9 | SDF | |
| Formula | C25H20N2O3S2 | M.Wt | 460.57 |
| Löslichkeit | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1712 mL | 10.8561 mL | 21.7122 mL |
| 5 mM | 0.4342 mL | 2.1712 mL | 4.3424 mL |
| 10 mM | 0.2171 mL | 1.0856 mL | 2.1712 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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