(Z)-4EGI-1 |
| Katalog-Nr.GC39842 |
(Z)-4EGI-1 ist das Z-Isomer von 4EGI-1 und ist ein Inhibitor der eIF4E/eIF4G-Interaktion und der Translationsinitiation. (Z)-4EGI-1 bindet effektiv an eIF4E mit einem IC50 von 43,5 μM und einem Kd-Wert von 8,74 μM. (Z)-4EGI-1 hat AntikrebsaktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 901787-88-0
Sample solution is provided at 25 µL, 10mM.
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(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].
[1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction. J Med Chem. 2014 Jun 26;57(12):5094-111.
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