(-)-Zuonin A |
| Katalog-Nr.GC60393 |
(-)-Zuonin A (D-Epigalbacin), ein natÜrlich vorkommendes Lignin, ist ein potenter, selektiver JNKs-Inhibitor mit IC50-Werten von 1,7 μM, 2,9 μM und 1,74 μM fÜr JNK1, JNK2 bzw. JNK3.
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Cas No.: 84709-25-1
Sample solution is provided at 25 µL, 10mM.
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(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
(-)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].(-)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation[1].
[1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (-)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873-1883.
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