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Deferitrin (Synonyms: GT-56-252, (S)-4'-Hydroxydesazadesferrithiocin)

Catalog No.GC52316

An iron chelator and derivative of desferrithiocin

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Deferitrin Chemical Structure

Cas No.: 239101-33-8

Size Price Stock Qty
5 mg
$455.00
In stock
10 mg
$865.00
In stock
25 mg
$2,045.00
In stock
50 mg
$3,634.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Deferitrin is an iron chelator and a derivative of desferrithiocin that binds iron in a 2:1 (ligand:iron) ratio.1,2 It inhibits the proliferation of L1210 murine leukemia cells (IC50 = 17 µM).3 Deferitrin (150 µmol/kg) induces iron excretion in iron-overloaded C. apella monkeys and beagle dogs with an iron clearing efficiency (ICE) of 14.5 and 9.3%, respectively.2 It reduces fecal and urine iron levels by 607 and 357 µg/kg in C. apella monkeys and beagle dogs, respectively.

1.Bergeron, R.J., Wiegand, J., Bharti, N., et al.Desferrithiocin analogue iron chelators: Iron clearing efficiency, tissue distribution, and renal toxicityBiometals24(2)239-258(2011) 2.Bergeron, R.J., Wiegand, J., Weimar, W.R., et al.Comparison of iron chelator efficacy in iron-overloaded beagle dogs and monkeys (Cebus apella)Comp. Med.54(6)664-672(2004) 3.Bergeron, R.J., Wiegand, J., Weimar, W.R., et al.Iron chelation promoted by desazadesferrithiocin analogs: An enantioselective barrierChirality15(7)593-599(2003)

Chemical Properties

Cas No. 239101-33-8 SDF Download SDF
Synonyms GT-56-252, (S)-4'-Hydroxydesazadesferrithiocin
Canonical SMILES OC1=C(C2=N[C@](C(O)=O)(C)CS2)C=CC(O)=C1
Formula C11H11NO4S M.Wt 253.3
Solubility DMF: 10 mg/mL,DMSO: 12 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.2 mg/mL Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.9479 mL 19.7394 mL 39.4789 mL
5 mM 0.7896 mL 3.9479 mL 7.8958 mL
10 mM 0.3948 mL 1.9739 mL 3.9479 mL
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