Di-4-ANEPPS |
Catalog No.GC43435 |
Di-4-ANEPPS is a fast-response membrane potential dye used to detect changes in membrane potential
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 90134-00-2
Sample solution is provided at 25 µL, 10mM.
Di-4-ANEPPS is a fast-response membrane potential dye used to detect changes in membrane potential[1]. Di-4-ANEPPS fluoresces to potential changes through very rapid structural changes, so they are suitable for detecting fast and transient potential changes in cells. Di-4-ANEPPS is rapidly internalized in cells and is therefore mainly used in short-term experiments[2]. Di-4-ANEPPS is a highly water-soluble microinjection, the fluorescence is not affected by cell and tissue types, and can be used to measure membrane potential in various tissues and cell types as well as in artificial membranes. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity[3].
References:
[1]. Maria Pura Hortigon-Vinagre, et al. The Use of Voltage Sensitive Dye di-4-ANEPPS and Video-Based Contractility Measurements to Assess Drug Effects on Excitation-Contraction Coupling in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. 2021 Mar 1;77(3):280-290. doi: 10.1097/FJC.0000000000000937.
[2]. LM Loew - Pure and Applied Chemistry. Potentiometric dyes: imaging electrical activity of cell membranes.1996 - degruyter.com
[3]. Marina Ronzhina, et al. Di-4-ANEPPS Modulates Electrical Activity and Progress of Myocardial Ischemia in Rabbit Isolated Heart. 2021 Jun 10;12:667065. doi: 10.3389/fphys.2021.667065. eCollection 2021.
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