Dipivefrin (hydrochloride) |
| Catalog No.GC43476 |
Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64019-93-8
Sample solution is provided at 25 µL, 10mM.
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Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine. It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM). Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM. In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity. Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM. Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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