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DNQX disodium salt (Synonyms: 6,7-Dinitroquinoxaline-2,3-dione)

Catalog No.GC10275

Selective non-NMDA receptor antagonist

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DNQX disodium salt Chemical Structure

Cas No.: 1312992-24-7

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Sample solution is provided at 25 µL, 10mM.

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Background

DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC50 = 40 μM for NMDA receptors).[1],[2],[3] This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.[4]

Reference:
[1]. Armstrong, N., and Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28(1), 165-181 (2000).
[2]. Honoré, T., Davies, S.N., Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988).
[3]. Lee, S.H., Govindaiah, G., and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J. Neurophysiol. 103(4), 1728-1734 (2010).
[4]. Muller, D., Joly, M., and Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242(4886), 1694-1697 (1988).

Chemical Properties

Cas No. 1312992-24-7 SDF
Synonyms 6,7-Dinitroquinoxaline-2,3-dione
Chemical Name sodium 6,7-dinitroquinoxaline-2,3-bis(olate)
Canonical SMILES [O-][N+](C1=C(C=C(C(N=C2[O-])=C1)N=C2[O-])[N+]([O-])=O)=O.[Na+].[Na+]
Formula C8H2N4O6Na2 M.Wt 296.1
Solubility 5mg/mL in DMSO, 12mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3772 mL 16.8862 mL 33.7724 mL
5 mM 0.6754 mL 3.3772 mL 6.7545 mL
10 mM 0.3377 mL 1.6886 mL 3.3772 mL
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