Docosanoic Acid-d4

Docosanoic acid-d₄ is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.^1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (K_d = 12 nM).³ Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.⁴ Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.⁵ Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.

1.Dean, L.L., and Sanders, T.H.Hexacosanoic acid and other very long-chain fatty acids in peanut seed oilPlant Genet. Resour.7(3)252-256(2009) 2.SÁnchez-Machado, D.I., LÓpez-Cervantes, J., NÚÑez-GastÉlum, J.A., et al.Effect of the refining process on Moringa oleifera seed oil qualityFood Chem.18753-57(2015) 3.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 4.Yonezawa, Y., Hada, T., Uryu, K., et al.Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerasesInt. J. Mol. Med.18(4)583-588(2006) 5.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016)