Dynorphin A (trifluoroacetate salt) (Synonyms: Dynorphin A (1-17))

Dynorphin A is a heptadecapeptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system, where it is implicated in antinociceptive functions.^1,2,3 It acts as an opioid receptor agonist with nanomolar binding affinity to the three major isotypes κ, µ, and δ (K_is = 0.5-1 nM) and has also been shown to activate human ORL1, a novel opioid receptor-like receptor (K_i = 386 nM).⁴

1.Berman, Y., Juliano, L., and Devi, L.A.Specificity of the dynorphin-processing endoprotease: Comparison with prohormone convertasesJ. Neurochem.72(5)2120-2196(1999) 2.Janecka, A., Fichna, J., and Janecki, T.Opioid receptors and their ligandsCurr. Top. Med. Chem.4(1)1-17(2004) 3.Dhawan, B.N., Cesselin, F., Raghubir, R., et al.International Union of Pharmacology. XII. Classification of opioid receptorsPharmacol. Rev.48(4)567-592(1996) 4.Zhang, S., Tong, Y., Tian, M., et al.Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene familyJ. Pharmacol. Exp. Ther.286(1)136-141(1998)