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E3 ligase Ligand 2 (Synonyms: 4-hydroxy Thalidomide)

Catalog No.GC32848

E3 ligase Ligand 2 (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. E3 ligase Ligand 2 (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.

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E3 ligase Ligand 2 Chemical Structure

Cas No.: 5054-59-1

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1g
$27.00
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2g
$41.00
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100mg
$90.00
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500mg
$225.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.

Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. E3 ligase Ligand 2 is a putative hydroxylated thalidomide metabolite. E3 ligase Ligand 2 has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). E3 ligase Ligand 2 does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].

[1]. Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.

Chemical Properties

Cas No. 5054-59-1 SDF
Synonyms 4-hydroxy Thalidomide
Canonical SMILES OC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
Formula C13H10N2O5 M.Wt 274.23
Solubility DMSO : ≥ 36.5 mg/mL (133.10 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.6466 mL 18.2329 mL 36.4657 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL
10 mM 0.3647 mL 1.8233 mL 3.6466 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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