E3 ligase Ligand-Linker Conjugates 11 (Synonyms: VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11) |
| Catalog No.GC32986 |
E3 ligase Ligand-Linker Conjugates 11 is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. E3 ligase Ligand-Linker Conjugates 11 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
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Cas No.: 1835705-61-7
Sample solution is provided at 25 µL, 10mM.
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E3 Ligase Ligand-Linker Conjugate 11 is a synthesized compound which incorporates a ligand for the E3 ubiquitin ligase and a PROTAC linker to bring together target protein and ubiquitinating machinery.
[1]. Ashton C. Lai, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11; 55(2): 807-810.
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