Home>>Signaling Pathways>> PROTAC>> E3 Ligase Ligand-Linker Conjugate>>E3 ligase Ligand-Linker Conjugates 6 Free Base

E3 ligase Ligand-Linker Conjugates 6 Free Base (Synonyms: VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base)

Catalog No.GC33111

E3 ligase Ligand-Linker Conjugates 6 Free Base (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.

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E3 ligase Ligand-Linker Conjugates 6 Free Base Chemical Structure

Cas No.: 2010159-60-9

Size Price Stock Qty
100mg
$280.00
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500mg
$1,080.00
In stock
1g
$1,980.00
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2g
$2,800.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

E3 ligase Ligand-Linker Conjugates 6 Free Base is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Chemical Properties

Cas No. 2010159-60-9 SDF
Synonyms VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base
Canonical SMILES O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Formula C28H41N5O6S M.Wt 575.72
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.737 mL 8.6848 mL 17.3696 mL
5 mM 0.3474 mL 1.737 mL 3.4739 mL
10 mM 0.1737 mL 0.8685 mL 1.737 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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