ELA-11 (human) |
| Catalog No.GC50550 |
High affinity apelin agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1784687-32-6
Sample solution is provided at 25 µL, 10mM.
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High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 . Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID:28137936 |Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID:26986036
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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