Eledoisin-Related Peptide (Synonyms: Eledoisin Hexapeptide, Eledoisin RP, KFIGLM-NH2, Lys-Phe-Ile-Gly-Leu-Met-NH2) |
| Catalog No.GC15230 |
Tachykinin receptor ligand
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2990-43-4
Sample solution is provided at 25 µL, 10mM.
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Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
Eledoisin Related Peptide shares with Substance P (SP) a common N-terminal amino acid sequence and has been shown by to have SP-like activity in the periphery (gut and salivary glands) and the CNS. Eledoisin-related peptide seems to be roughly equipotent with Substance P at identical ejection currents on the single-cell activity of neurons in this nucleus[2]. Both glutamate and substance P (and its analogue, eledoisin-related peptide) have excitatory effects on the activity of respiratory neurons and reflex interneurons[3].
References:
[1]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322.
[2]. Guyenet PG, et al. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Res. 1977 Nov 4;136(1):178-84.
[3]. Henry JL, et al. Effects of glutamate, substance P and eledoisin-related peptide on solitary tract neurones involved in respiration and respiratory reflexes. Neuroscience. 1985 Mar;14(3):863-73.
Animal experiment: | Rats[2]Twenty-two male albino rats (230-260 g) are anesthetized with chloral hydrate (400 mg/kg, i.p.) and prepared for recording. Briefly, a singlebarrel recording pipette (tip 1 μm) is glued alongside a conventional five-barrel micropipette (tip 15-25/μm) then filled with 2 M NaCI saturated with Fast Green (impedance 4-7 M). The distance between the tip of the recording electrode and that of the five-barrel micropipette is 15-25/zm. Fast Green is ejected at the end of the experiment to identify the recording site. One side barrel of the five-barrel micropipette is loaded with 4 M NaCI for automatic current balancing and the others with three of the following solutions: L-epinephrine bitartrate (0. l M, pH 4.0), L-norepinephrine bitartrate (0.1 M, pH 4.0), Substance P (2.75 mM), physalaemin (2.6 mM), substance P 4-11 octapeptide (3.1 mM), eledoisin-related peptide (20 mM), neurotensin, bradykinin triacetate (15 mM), met-enkephalin (6.5 mM), TRH (48 mM). Spontaneously active cells are recorded in the locus coeruleus or in the nearby mesencephalic nucleus of the fifth nerve whose cells are easily identified by their increased activity upon manipulation of the jaw[2]. |
References: [1]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322. | |
| Cas No. | 2990-43-4 | SDF | |
| Synonyms | Eledoisin Hexapeptide, Eledoisin RP, KFIGLM-NH2, Lys-Phe-Ile-Gly-Leu-Met-NH2 | ||
| Chemical Name | (S)-2,6-diamino-N-((5S,8S,14S,17S)-14-((S)-sec-butyl)-5-carbamoyl-8-isobutyl-7,10,13,16-tetraoxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadecan-17-yl)hexanamide | ||
| Canonical SMILES | O=C([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCCN)N)=O)=O)NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O | ||
| Formula | C34H58N8O6S | M.Wt | 706.94 |
| Solubility | Soluble in water | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4145 mL | 7.0727 mL | 14.1455 mL |
| 5 mM | 0.2829 mL | 1.4145 mL | 2.8291 mL |
| 10 mM | 0.1415 mL | 0.7073 mL | 1.4145 mL |
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Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
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- SDS (Safety Data Sheet)
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Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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