ENMD-1068 hydrochloride (Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride) |
| Catalog No.GC60807 |
Selective protease-activated receptor 2 (PAR2) anatagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 789488-77-3
Sample solution is provided at 25 µL, 10mM.
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ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist with antiangiogenic and anti-inflammatory activities. ENMD-1068 hydrochloride reduces epatic stellate cells (HSCs) activation and collagen expression through the inhibiton of TGF-β1/Smad signal transduction[1][2].
[1]. Yifeng Wang, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8. [2]. Quan Sun, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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