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EP1013 (F1013) (Synonyms: F1013)

Catalog No.GC31390

EP1013 (F1013) (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

Products are for research use only. Not for human use. We do not sell to patients.

EP1013 (F1013) Chemical Structure

Cas No.: 223568-55-6

Size Price Stock Qty
10mM (in 1mL DMSO)
$170.00
In stock
1mg
$101.00
In stock
5mg
$202.00
In stock
10mg
$321.00
In stock
50mg
$911.00
In stock
100mg
$1,471.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].

[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.

Chemical Properties

Cas No. 223568-55-6 SDF
Synonyms F1013
Canonical SMILES O=C(O)C[C@H](NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)C(CF)=O
Formula C18H23FN2O6 M.Wt 382.38
Solubility DMSO : ≥ 60 mg/mL (156.91 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6152 mL 13.076 mL 26.152 mL
5 mM 0.523 mL 2.6152 mL 5.2304 mL
10 mM 0.2615 mL 1.3076 mL 2.6152 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for EP1013 (F1013)

Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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