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Epiblastin A

Catalog No.GC43618

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively).

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Epiblastin A Chemical Structure

Cas No.: 16470-02-3

Size Price Stock Qty
1mg
$33.00
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5mg
$105.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively). [1] It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene .

Reference:
[1]. Ursu, A., Illich, D.J., Takemoto, Y., et al. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of Casein Kinase 1. Cell Chem. Biol. 23(4), 494-507 (2016).

Chemical Properties

Cas No. 16470-02-3 SDF
Chemical Name 6-(3-chlorophenyl)-2,4,7-pteridinetriamine
Canonical SMILES NC1=NC2=NC(N)=NC(N)=C2N=C1C3=CC(Cl)=CC=C3
Formula C12H10ClN7 M.Wt 287.7
Solubility Soluble in DMSO & DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4758 mL 17.3792 mL 34.7584 mL
5 mM 0.6952 mL 3.4758 mL 6.9517 mL
10 mM 0.3476 mL 1.7379 mL 3.4758 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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