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Ethylmalonyl Coenzyme A Catalog No.GC19430

A key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 6049-57-6 SDF Download SDF
Synonyms Ethylmalonyl-CoA
Chemical Name S-(hydrogen 2-ethylpropanedioate) coenzyme A
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C(C(O)=O)CC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O
Formula C26H42N7O19P3S M.Wt 881.6
Solubility 10mg/mL in PBS, pH 7.2 Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such as M. extorquens, which uses this pathway when grown on ethylamine.[1],[2] It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA.

[1]. Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al. Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1 J. Bacteriol. 197(4), 727-735 (2015).
[2]. Anthony, C. How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway Sci. Prog. 94(Pt 2), 109-137 (2011).