Exendin-4 (5-39) amide (trifluoroacetate salt) (Synonyms: Exenatide Amide) |
| Catalog No.GC52411 |
An antagonist of the GLP-1 receptor
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Exendin-4 (5-39) amide is a 34-amino acid synthetic peptide corresponding to residues 5-39 of exendin-4 (48-86) amide and an antagonist of the glucagon-like peptide 1 (GLP-1) receptor (IC50 = 0.3 nM) that has roles in synaptic transmission.1 It decreases GLP-1-induced increases in intracellular cAMP levels in CHO/pancGLPR cells. Exendin-4 (5-39) amide (10 and 100 nM) increases extracellular glutamate reuptake in primary rat hippocampal astrocytes.2 In vivo, exendin-4 (5-39) amide increases excitatory amino acid transporter 2 (EAAT2) protein levels and decreases the field excitatory postsynaptic potential decay time in the rat dentate gyrus when administered intracerebroventricularly.
1.Montrose-Rafizadeh, C., Yang, H., Rodgers, B.D., et al.High potency antagonists of the pancreatic glucagon-like peptide-1 receptorJ. Biol. Chem.272(34)21201-21206(1997) 2.Kobayashi, K., Iwai, T., Sasaki-Hamada, S., et al.Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrusBrain Res.15051-10(2013)
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