Fenoprofen-13C6 (sodium salt hydrate) |
| Catalog No.GC91909 |
Fenoprofen-13C6 is intended for use as an internal standard for the quantification of fenoprofen by GC- or LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2687960-29-6
Sample solution is provided at 25 µL, 10mM.
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Fenoprofen-13C6 is intended for use as an internal standard for the quantification of fenoprofen by GC- or LC-MS. Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).1 It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching and formalin-induced licking behaviors in mice, however, it also induces the formation of gastric lesions in mice.2 Formulations containing fenoprofen have been used in the treatment of pain and the signs and symptoms of rheumatoid arthritis and osteoarthritis.
References:
[1]. Patrono, C., Ciabattoni, G., and Grossi-Belloni, D.In vitro and in vivo inhibition of prostaglandin synthesis by fenoprofen, a non steroid anti-inflammatory drugPharmacol. Res. Commun.6(5)509-518(1974).
[2]. Agotegaray, M., Gumilar, F., Boeris, M., et al.Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: Promising insights in the treatment of chronic inflammatory diseasesBiomed. Res. Int.505987(2014).
| Cas No. | 2687960-29-6 | SDF | |
| Chemical Name | α-methyl-3-(phenoxy-1,2,3,4,5,6-13C6)-benzeneacetic acid, monosodium salt, hydrate | ||
| Canonical SMILES | CC(C1=CC=CC(O[13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)=C1)C([O-])=O.[Na+].O | ||
| Formula | C9[13C]6H13O3 ? Na [XH2O] | M.Wt | 270.2 |
| Solubility | DMSO: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.701 mL | 18.5048 mL | 37.0096 mL |
| 5 mM | 0.7402 mL | 3.701 mL | 7.4019 mL |
| 10 mM | 0.3701 mL | 1.8505 mL | 3.701 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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