Home>>Signaling Pathways>> Metabolism>> Ferroptosis>>Ferrostatin-1 (Fer-1)
Ferrostatin-1 (Fer-1) Catalog No.GC10380

Ferroptosis inhibitor, erastin-induced

Size Price Stock Qty
10mM (in 1mL DMSO)
In stock
In stock
In stock
In stock

Customer Review

Based on customer reviews.

Tel: (626) 353-8530 Email: [email protected]

Sample solution is provided at 25 µL, 10mM.

Product Citations

Quality Control

Quality Control & SDS

View current batch:


Cell experiment [1]:

Cell lines

Healthy medium spiny neurons, oligodendrocytes, kidney proximal tubules cell

Preparation method

The solubility of this compound in DMSO is >9.8mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10 nM, 100 nM, and 1 μM


Fer-1 (10 nM, 100 nM, and 1 μM) significantly increased the number of healthy MSNs. Fer-1 (1 μM) statistically increased the number of healthy MSN. Fer-1 (100 nM) fully protected oligodendrocytes from cystine deprivation. Fer-1 (0.1-2 μM) prevented lethality induced by hydroxyquinoline and ferrous ammonium sulfate (HQ + Fe; 10 μM each).

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1]. Skouta R, Dixon S J, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models[J]. Journal of the American Chemical Society, 2014, 136(12): 4551-4556.

Chemical Properties

Cas No. 347174-05-4 SDF
Synonyms N/A
Chemical Name N/A
Formula C15H22N2O2 M.Wt 262.35
Solubility ≥ 9.8 mg/mL in DMSO, ≥ 99.6 mg/mL in EtOH with ultrasonic Storage 4°C, protect from light
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
  • Molarity Calculator

  • Dilution Calculator

**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.

Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2].

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72.
[2]. Kabiraj P, et al. The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells. Protein J. 2015 Oct;34(5):349-58.