FK 3311 (Synonyms: COX-2 Inhibitor V) |
Catalog No.GC11768 |
A COX-2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 116686-15-8
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
FK 3311, a cell-permeable and orally available sulfonanilide, is a highly selective inhibitor of cyclooxygenase (COX)-2 with IC 50 value of 1.6 μM.
Cyclooxygenase-2 (COX-2) is a membrane bound enzyme that transfers the electrons from cytochrome c to the catalytic subunit 1. The expression of COX-2 is tightly regulated and induced by different mediators such as cytokine, growth factor, and endotoxin.
FK3311 was shown to selectively inhibit consititutive and inducible COX-2 activity in human platelets and mononuclear cells [1].
The component has also been used extensively in various animal models to study the role of COX-2. In ischemia-reperfusion rat model, administration of FK 3311 via the penile vein can significantly reduce the serum levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and thromboxane (Tx) B2. However, FK 3311 treatment did not reduce the 6-keto-PG F1a levels in these rats[2]. In addition, liver tissue blood flow was remarkably better in the FK3311 treated rat compared with their control group. Histological examination of the livers revealed that FK3311 treatment reduced the hepatic tissue damage and improved the liver graft function [3]. In the canine lung transplantation model, treatment of FK3311 reduced lung damage, neutrophil infiltration into lung, technetium-99m-albumin accumulation and thromboxane B2 level. The lung with FK3311 treatment had better pulmonary gas exchange and hemodynamics [4].
References:
1.Grossman CJ, Wiseman J, Lucas FS, Trevethick MA, Birch PJ. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm Res 1995,44:253-257.
2.Kobayashi M, Takeyoshi I, Kurabayashi M, Matsumoto K, Morishita Y. The effects of a cyclooxygenase-2 inhibitor, FK3311, on total hepatic ischemia-reperfusion injury of the rat. Hepatogastroenterology 2007,54:522-526.
3.Oshima K, Yabata Y, Yoshinari D, Takeyoshi I. The effect of cyclooxygenase (COX)-2 inhibition on ischemia-reperfusion injury in liver transplantation. J Invest Surg 2009,22:239-245.
4.Sunose Y, Takeyoshi I, Tsutsumi H, Ohwada S, Oriuchi N, Matsumoto K, et al. Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model. Ann Thorac Surg 2001,72:1165-1171; discussion 1171-1162.
Cas No. | 116686-15-8 | SDF | |
Synonyms | COX-2 Inhibitor V | ||
Chemical Name | N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide | ||
Canonical SMILES | CC(=O)C1=CC(=C(C=C1)NS(=O)(=O)C)OC2=C(C=C(C=C2)F)F | ||
Formula | C15H13F2NO4S | M.Wt | 341.33 |
Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.9297 mL | 14.6486 mL | 29.2972 mL |
5 mM | 0.5859 mL | 2.9297 mL | 5.8594 mL |
10 mM | 0.293 mL | 1.4649 mL | 2.9297 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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