Fluzinamide (AHR-8559) |
Catalog No.GC33509 |
Fluzinamide (AHR-8559) is an effective antiepileptic.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76263-13-3
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fluzinamide is an effective antiepileptic.
Fluzinamide, an antiepileptic agent effective against partial seizures, is metabolized extensively in mice, rats and dogs[1].The anticonvulsant properties of Fluzinamide (AHR-8559) are evaluated in the kindled amygdaloid seizure model in rats. Fluzinamide significantly attenuates afterdischarge durations and the severity of the accompanying convulsive responses in previously kindled rats at doses that does not cause sedation or ataxia. After acute intraperitoneal injections, the maximum anticonvulsant effectiveness against suprathreshold (400 μA) stimulation is seen at 30 min. Fluzinamide (10-80 mg/kg i.p.) is also evaluated in kindled rats using threshold (20 μA increments) seizures. Low doses of Fluzinamide significantly elevate seizure threshold and reduce both elicited after discharge durations and seizure severity. When administered daily during kindling acquisition, Fluzinamide (20 and 40 mg/kg i.p.) significantly increases the number of trials necessary to complete kindling. The duration and the severity of the responses induced by stimulations during the acquisition period are reduced[2].
[1]. Johnson DN, et al. Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents. Epilepsy Res. 1990 Apr;5(3):185-91. [2]. Albertson TE, et al. Anticonvulsant action of fluzinamide (AHR-8559) on kindled amygdaloid seizures. Epilepsia. 1984 Aug;25(4):511-7.
Cas No. | 76263-13-3 | SDF | |
Canonical SMILES | O=C(N1CC(OC2=CC=CC(C(F)(F)F)=C2)C1)NC | ||
Formula | C12H13F3N2O2 | M.Wt | 274.24 |
Solubility | Soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.6464 mL | 18.2322 mL | 36.4644 mL |
5 mM | 0.7293 mL | 3.6464 mL | 7.2929 mL |
10 mM | 0.3646 mL | 1.8232 mL | 3.6464 mL |
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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