1,2,3,4-Tetrahydrostaurosporine (Synonyms: AFN-941) |
| Catalog No.GC46039 |
A mutant EGFR inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220038-19-7
Sample solution is provided at 25 µL, 10mM.
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1,2,3,4-Tetrahydrostaurosporine is a derivative of staurosporine and an inhibitor of mutant EGFR (IC50 = 74 nM for EGFRT790M).1 It is selective for EGFRT790M over wild-type EGFR (IC50 = 390 nM). It also binds to Janus kinase 3 (JAK3).2
|1. Song, X., Liu, X., and Ding, X. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4), (2017).|2. Boggon, T.J., Li, Y., Manley, P.W., et al. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).
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