1-Arachidonoyl Lysophosphatidic Acid (ammonium salt) (Synonyms: 1-Arachidonoyl LPA, 1-Arachidonoyl-sn-glycero-3-phosphate, 1-Eicosatetraenoyl-sn-glycero-3-PA, 20:4 Lyso PA, LPA(20:4), PA(20:4/0:0)) |
| Catalog No.GC41986 |
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position.
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Cas No.: 799268-65-8
Sample solution is provided at 25 µL, 10mM.
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.
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