Accueil>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>> Akt>>10-DEBC hydrochloride

10-DEBC hydrochloride (Synonyms: Akt Inhibitor X)

Catalog No.GC13006

Le chlorhydrate de 10-DEBC est un inhibiteur sélectif de l'Akt, avec une IC50 de 1,28 μM.

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10-DEBC hydrochloride Chemical Structure

Cas No.: 925681-41-0

Taille Prix Stock Qté
1mg
63,00 $US
En stock
5mg
166,00 $US
En stock
10mg
213,00 $US
En stock
50mg
840,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM.[1] This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM.[1] Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.[1]

Reference:
[1]. Thimmaiah, K.N., Easton, J.B., Germain, G.S., et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. The Journal of Biological Chemisty 280(36), 31924-31935 (2005).

Chemical Properties

Cas No. 925681-41-0 SDF
Synonymes Akt Inhibitor X
Chemical Name 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride
Canonical SMILES ClC1=CC=C2OC3=CC=CC=C3N(C2=C1)CCCCN(CC)CC.Cl
Formula C20H25N2OCl.HCl M.Wt 381.34
Solubility 16mg/mL in ethanol, 12.5mg/mL in DMSO, 5mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1117 mL 26.2233 mL
5 mM 0.5245 mL 2.6223 mL 5.2447 mL
10 mM 0.2622 mL 1.3112 mL 2.6223 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

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